Calecim Professional Skincare and PTT-6 Technology traces the brand’s science standout products and pricing for shoppers weighing whether it’s worth trying.
Key Takeaways
- The active ingredient, PTT-6, comes from red deer umbilical cords, not humans or plants.
- A 2019 clinical trial and later eyelid specific study back up several of the brand’s claims.
- Prices range from $65 for a starter kit to $360 for the hair serum.
- Calecim started as a doctor only brand, and its physicians’ directory still reflects that today.
Why Calecim Professional Stands Out
Most skincare brands start with a marketing idea and work backward to find an ingredient. Calecim Professional Skincare went the other way. Its parent company, CellResearch Corporation, was founded in Singapore in 2002 to study skin and scar cell biology, not to sell cosmetics. Two years later, in 2004, its scientists discovered stem cells in the umbilical cord lining, a source they would spend the next decade researching for wound healing rather than beauty.
That research only became a skincare line in 2016, when CALECIM® Professional launched using the same active ingredient developed for recovery and repair. The ingredient itself, PTT-6, is sourced from the umbilical cord lining of red deer, not humans or plants, which is unusual in a category where most “stem cell” products lean on human or plant derived alternatives.
For years, this wasn’t something you could simply add to cart. CALECIM® Professional was sold exclusively through doctors and clinics before it ever reached direct to consumer shelves. That clinical starting point is still the clearest thing separating it from a typical skincare brand.
What Is PTT-6? The Science Behind Every Product
Every product in the Calecim Professional range runs on a single active ingredient: PTT-6. It’s a proprietary blend of proteins, cytokines, growth factors, and exosomes, all derived from red deer umbilical cord lining stem cells, the same source that traces back to CellResearch Corporation’s original wound healing research. Rather than formulating different actives for different concerns, the brand built its entire skin and hair line, from the Professional Serum to the Hair Serum, around this one ingredient complex.
The intent behind PTT-6 is to work at the cellular level. In skin, that means supporting the processes tied to elasticity, hydration, and tone. In the scalp, it’s aimed at the follicle environment itself, addressing the kind of inflammation that can interfere with healthy hair growth.
Calecim Professional publishes a set of headline figures tied to PTT-6: a 56% increase in elastin production, an 83% increase in hyaluronic acid production, a 24% increase in hair follicle cell production, and a 30x decrease in scalp inflammation. These are the brand’s own reported figures, drawn from its research and marketing materials. They haven’t been independently verified outside of the company’s published claims, so it’s worth treating them as company reported data rather than confirmed, third party benchmarks.
The Clinical Research and Physician Network Behind Calecim
What sets Calecim Professional apart from most direct to consumer skincare brands isn’t just the ingredient story, it’s that some of the underlying claims have actually been tested in published, checkable research.
In 2019, the Journal of Drugs in Dermatology published a randomized, double blind, split face, placebo controlled trial involving 40 subjects, comparing the effects of the red deer stem cell extract cream against a vehicle cream on facial photodamage. That’s a real clinical design, not a marketing survey. Separately, an in-vitro study on human dermal fibroblasts found that exposure to the conditioned media increased elastin production by 56% and hyaluronic acid production by 83% compared to a control medium. A follow up study focused specifically on eyelid skin found even larger effects in that thinner tissue: elastin up 68% and hyaluronic acid up 113%.
Named clinicians also back the brand’s claims with their own observations. Dr Manav Bawa, medical director at Time Clinic in London, ran a small evaluation of 12 perimenopausal women using the Calecim protocol and reported visible changes in hair thickness and texture among participants by around 12 weeks. His work and commentary on regenerative hair restoration were later featured in the New York Times.
At the same time, it’s worth being direct about what Calecim Professional is not. The official site states plainly that its products meet the FDA’s definition of a cosmetic, meaning something applied to cleanse, beautify, or alter appearance. They are not approved by the FDA as drugs, and the company does not claim they diagnose, treat, cure, or prevent any disease or condition. That distinction matters when weighing the clinical research against what the product is actually allowed to claim on the label.
Product Highlights
Every product below uses the same PTT-6 complex, but each one connects to a different piece of Calecim Professional’s verified research or history, from the clinical trial behind the Multi Action Cream to the eyelid specific study behind the Eye Contour Lifting Cream. Here’s a closer look at five products from the range and what makes each one relevant.
Professional Serum 5ml
The Professional Serum is Calecim Professional’s most concentrated product, containing the highest level of PTT-6 across the entire range. It’s built for both daily use and post treatment recovery, making it suited to anyone using it as part of a regular skincare routine, after at home microneedling or chemical peels, or following clinical skin treatments. A single pipette is designed to work into existing skincare routines rather than replace them.
- Contains the highest concentration of PTT-6 in the Calecim Professional lineup
- Formulated with PTT-6, growth factors, exosomes, albumin, and fibronectins, containing over 3,000 proteins that signal cells to regenerate
- Targets fine lines, wrinkles, and hyperpigmentation while keeping skin supple
- Suited to three specific use cases: daily skincare, after at home microneedling or chemical peels, and after clinical skin treatments
- Comes in a 5ml size, yielding approximately 10 pipettes per bottle
Price: $100.00 USD for 5ml.
Multi-Action Cream 20g Starter Size Kit
This cream is tied to Calecim Professional’s strongest piece of published research, the 2019 Journal of Drugs in Dermatology trial. That study was randomized, double blind, split face, and placebo controlled. The 20g starter size gives you a smaller way into that same formula.
It’s meant for everyday use, not just for after a procedure. If you’re dealing with skin laxity or want more firmness as part of your regular routine, this is built for that. You don’t have to buy the full size jar just to try it out.
- Made with PTT-6, plus linolenic acid, soluble collagen, hyaluronic acid, lactic acid, and tocopherol
- This is the exact formula used in the 2019 JDD clinical trial (randomized, double blind, split face, placebo controlled)
- Meant to boost collagen and elastin so skin looks lifted and firmer
- One aesthetic practitioner said it gives visible lift and tightening
- You apply it twice a day, morning and night
Price: $85.00 USD for the 20g starter size. You can also split it into 3 interest free payments of $28.33 USD through SplitIt.
Hair Serum
The Hair Serum is Calecim Professional’s 6-week hair restoration program, built around the same PTT-6 complex used across the rest of the range. It’s the product most directly tied to the brand’s menopause hair loss research, including Dr Manav Bawa’s evaluation of perimenopausal women and the resulting New York Times feature. It’s aimed at people dealing with hair thinning or shedding, including those who haven’t seen results from Minoxidil.
- Applied twice a week with a derma stamp during the initial 6-week treatment phase, then once a week during maintenance
- PTT-6 is linked to a 24% increase in hair follicle cell production and a 30x reduction in follicle inflammation, a key driver of hair loss
- Kelly Morrell, a scalp technician, has noted it delivering results even in patients unresponsive to Minoxidil
- Formulated with PTT-6, growth factors, and exosomes, containing over 3,000 proteins that signal cells to regenerate
Price: $360.00 USD one time, or $288.00 USD through the Auto Replenish subscription, which comes with a minimum commitment of 3 delivery cycles.
Eye Contour Lifting Cream
The Eye Contour Lifting Cream is built around a study specific to eyelid skin, separate from the broader facial skin research behind other products in the range. That study measured how PTT-6 affected elastin and hyaluronic acid production in eyelid derived skin cells, since skin around the eyes behaves differently from skin elsewhere on the face. It’s aimed at people dealing with thinning, crepey under eye skin, discoloration, or puffiness.
- Formulated with PTT-6 alongside fibronectins, glycoproteins, collagen, and hyaluronic acid to support skin renewal
- Contains guarana extract, a natural source of caffeine molecules, to help increase micro circulation
- Includes matrikines, peptides that help break down blood originated pigments linked to dark circles
- Backed by a dedicated study on eyelid derived skin cells, distinct from the brand’s general facial skin research
- Applied AM and PM
Price: $160.00 USD one time for 15ml, or $128.00 USD through the Auto Replenish subscription, which requires a minimum commitment of 3 delivery cycles. A 3 interest free payment option of $53.33 USD is also available through SplitIt.
Recovery Night Complex 30g Starter Size Kit
The Recovery Night Complex is the lowest priced entry point into Calecim Professional’s PTT-6 lineup, and this 30g starter size makes it even more accessible. It’s worn overnight and rinsed off in the morning, aimed at people dealing with dull, dry, or sensitized skin who want to ease into the brand’s research backed formula without committing to a full size product. It’s also sold as part of the Power Bundle alongside the Professional Serum.
- Formulated with PTT-6, calmosensine, cucumis sativus extract, allantoin, and albumin
- Contains hyaluronic acid and sodium hyaluronate for overnight hydration
- Worn through the night and washed off in the morning
- Works to regenerate skin cells while you sleep, not just calm and hydrate on the surface
- Available paired with the Professional Serum as part of the brand’s Power Bundle
Price: $65.00 USD for the 30g starter size, with an option of 3 interest free payments of $21.67 USD through SplitIt.
Who Calecim Professional Is Designed For
Calecim Professional Skincare isn’t built for casual browsing. It grew out of wound recovery research, so its core audience has always been people managing a specific skin or scalp concern rather than shoppers just trying something new.
The clearest fit is anyone recovering from an in clinic procedure. Products like the Professional Serum are specifically recommended by doctors for use right after laser treatments, microneedling, or chemical peels, and for about a week afterward. On the hair side, the brand’s research leans heavily toward menopausal and perimenopausal women dealing with thinning hair, including Dr Manav Bawa’s evaluation of 12 perimenopausal women that later fed into New York Times coverage. The Hair Serum has also been noted by a scalp technician as effective in patients who didn’t see results from Minoxidil, which makes it relevant to anyone who’s already tried that route.
Outside those two clinical cases, the range also suits people who just want a daily anti aging routine at home, using products like the Multi Action Cream or Recovery Night Complex on their own schedule. And since the brand started as a doctor exclusive product before it ever sold direct to consumers, it’s still used by clinics and aesthetic practices as part of their in office protocols today.
- Post procedure skin recovery, following laser, microneedling, or chemical peels
- Menopause related hair thinning, backed by clinical evaluation and physician commentary
- At home use for general anti aging, without a specific procedure or condition
In clinic use through aesthetic practices, reflecting the brand’s original distribution model
Buying Guide for US Customers
Ordering from the United States is straightforward, but there are a few specifics worth knowing before you check out.
Orders within the US typically take 3 to 6 working days to arrive. The US is also one of the three countries, alongside Singapore and the UK, where Calecim Professional absorbs shipping and country tax on your behalf. That said, state tax may still apply depending on where you live, so don’t be surprised if it shows up at checkout in certain states.
If you plan on reordering regularly, the MyCALECIM® Auto Replenish subscription is worth considering. It offers up to 20% off each delivery cycle, free express delivery, and credits that offset upcoming cycles. Cancellation is available after a minimum commitment of 3 delivery cycles, so it’s not a one and done sign up.
Separately, the MyCALECIM® Rewards Club is built around earning your way to free products rather than just discounts. Members get access to discount vouchers, the ability to try the full range of products, and ongoing product sampling programs.
For one time savings, Calecim Professional currently lists two standing offers on its site: a 10% discount for signing up with your email, and a referral program that gives both you and a friend 15% off when you introduce them to the brand’s PTT-6 hair solution. Neither is presented as a limited time deal, just an ongoing part of how the site is set up.
- US orders ship in 3 to 6 working days, with shipping and country tax absorbed, though state tax may still apply
- Auto Replenish includes up to 20% off per cycle, free express delivery, and cancellation after a 3-cycle minimum
- Rewards Club includes discount vouchers and access to product sampling programs
A 10% email sign up discount and a 15% two way referral discount are both currently listed on site
What Customers Say About Calecim Professional
Calecim Professional sits at around 4 stars on Trustpilot, based on 966 reviews as of the latest snapshot. That number hasn’t just sat still either. It went from 791 reviews up to over 900 in just a few months, which points to a steady stream of new customers weighing in, not some one time burst.
Most of the praise comes back to results. People often bring up better skin texture, more firmness, and improved hydration, especially with products like the Multi Action Cream.
The Hair Serum gets a lot of mentions too. A few reviewers said it worked for them even after Minoxidil didn’t, which lines up with what a scalp technician has said about it separately.
With this many reviews, some feedback naturally touches on the service side too, not just the product itself. That’s pretty normal for any platform with hundreds of entries, and it doesn’t take away from the overall pattern of people reporting good results.
- Trustpilot rating of approximately 4 stars based on 966 reviews
- Most common praise centers on improved texture, firmness, and hydration, along with hair serum results
Some service related feedback also appears among the reviews, as is typical on a platform with this volume
Finding a Calecim Professional Provider
Before Calecim Professional ever sold directly to consumers, it was only available through doctors and clinics. That history still shows up today through the brand’s Physicians’ Directory, which connects patients to clinics offering in-office treatments with the product.
If you’re interested in a professional administered treatment, whether that’s a post procedure recovery protocol or an in clinic hair session, the Pro Directory is the place to start. It’s a direct link to the same clinical channel Calecim Professional was built on, before the at home range ever existed. For anyone weighing an in office option against ordering products to use at home, checking the directory is a practical first step.
Summary
This blog looked at five products from the Calecim Professional Skincare range. That includes the Professional Serum, which has the highest PTT-6 concentration in the lineup, down to the Recovery Night Complex, the lowest priced option. It also covered some practical buying details for US customers, like the 3 to 6 working day shipping window and the MyCALECIM® Auto Replenish subscription, which knocks up to 20% off each cycle but comes with a minimum 3-cycle commitment.
A couple of products really stood out, and not just because of how they’re marketed. The Multi Action Cream is the exact formula used in the 2019 Journal of Drugs in Dermatology clinical trial. The Eye Contour Lifting Cream has its own separate study too, this one focused specifically on eyelid skin. Then there’s the Hair Serum, which connects directly to Dr Manav Bawa’s work with perimenopausal women, later picked up by the New York Times. That’s the kind of research trail you can actually go check for yourself.
If you’re not sure where to start, the Recovery Night Complex 30g starter kit at $65 is a cheaper way to try the PTT-6 formula before going all in on a full size product. And if you’re recovering from an in office procedure, or already seeing a provider, the brand’s Pro Directory can point you toward a clinic that offers these treatments directly.
